Answer:

1. Shut down Foxhound if it is running.

2. Create a folder for the transaction log on a different physical drive; e.g., G:\data\foxhound_log

3. Move the foxhound5.log file to that folder. By default, foxhound5.log is installed in this location on Windows 10:

   C:\ProgramData\RisingRoad\Foxhound5

4. Run dblog.exe to modify the foxhound5.db file to point to the new location for the foxhound5.log file:

            "C:\Program Files\SQL Anywhere 16\Bin64\dblog.exe" -t "G:\data\foxhound_log\foxhound5.log" "C:\ProgramData\RisingRoad\Foxhound5\foxhound5.db"
            

5. Here's what the output looks like:

   C:\temp>"C:\Program Files\C:\Program Files\SQL Anywhere 16\Bin64\dblog.exe" -t "G:\data\foxhound_log\foxhound5.log" "C:\ProgramData\RisingRoad\Foxhound5\foxhound5.db" SQL Anywhere Transaction Log Utility Version 17.0.9.4882 "C:\ProgramData\RisingRoad\Foxhound5\foxhound5.db" was using log file "foxhound1.log" "C:\ProgramData\RisingRoad\Foxhound5\foxhound5.db" is using no log mirror file "C:\ProgramData\RisingRoad\Foxhound5\foxhound5.db" is now using log file "G:\data\foxhound_log\foxhound5.log" Transaction log starting offset is 0011371032 Transaction log current relative offset is 0474894106

6. Now you can start Foxhound again.

See also...
How do I move Foxhound to a different disk drive?
How do I move the Foxhound database to a different location?